3426-71-9 N-苄氧羰基羟胺

常温运输。危险性质：非危险化学品。WGK Germany:3，RTECS号:FB1600000，F:21，海关编码:29280000，存储类别:11 - 可燃固体

化学合成；作为医药合成中间体（如替格瑞洛合成）；用于Diels-Alder反应。

医药合成中间体; Diels-Alder反应

路线1：

• 步骤: 将碳酸钠和纯水溶解，加入盐酸羟胺，室温搅拌下滴加氯甲酸苄酯的二氯甲烷溶液，滴加后继续搅拌，加水分离，水层用二氯甲烷萃取，合并有机相，饱和盐水洗涤，无水硫酸钠干燥，减压蒸馏得粗品，经二氯甲烷溶解、石油醚结晶、混合溶剂洗涤、减压干燥得产物。
• 条件: 20℃，1h；滴加约4h；45℃减压蒸馏；0℃结晶1h。
• 收率: 64%。
• 参考文献: [1] Organic and Biomolecular Chemistry, 2009, vol. 7, #21, p.4531-4538；[2] Journal of Organic Chemistry, 2009, vol.74, #22, p.8690-8694；[3] Journal of the American Chemical Society, 2010, vol.132, #37, p.12862-12864；[4] Synthetic Communications, 2010, vol.40, #5, p.642-646；[5] Helvetica Chimica Acta, 1991, vol.74, #8, p.1653-1670；[6] Patent: CN107936040, 2018, A.；[7] Organic Letters, 2017, vol.19, #24, p.6574-6577；[8] Journal of the American Chemical Society, 1914, vol.36, p.2222；[9] Journal of the Chemical Society, 1960, p.229-238；[10] Journal of the Chemical Society [Section] C: Organic, 1966, p.354-358；[11] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1979, p.2138-2143；[12] Organic and Biomolecular Chemistry, 2004, vol.2, #5, p.695-700；[13] Organic and Biomolecular Chemistry, 2016, vol.14, #23, p.5224-5228；[14] Organic Letters, 2016, vol.18, #21, p.5560-5563；[15] Journal of Organic Chemistry, 2017, vol.82, #15, p.8251-8257；[16] Organic and Biomolecular Chemistry, 2018, vol.16, #14, p.2421-2426；[17] Journal of Organic Chemistry, 2018, vol.83, #15, p.8233-8240。