- 英文名称
- palonosetron hydrochloride
- 分子式
- C19H25ClN2O
- 分子量
- 332.87
- 中文别名
- 盐酸帕洛诺司琼; (S)-2-((S)-奎宁环-3-基)-2,3,3a,4,5,6-六氢-1H-苯并[de]异喹啉-1-酮盐酸盐; 盐酸帕拉诺司琼; (3aS)-2-[(3S)-1-azabicyclo[2.2.2]octan-3-yl]-3a,4,5,6-tetrahydro-3H-benzo[de]isoquinolin-1-one,hydrochloride; (S)-2-((S)-Quinuclidin-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride; PALONOSETRON HCL; Palonosetron hydrochloride; (3aS)-2-(3S)-1-Azabicyclo[2.2.2]oct-3-yl-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; RS 25259-197; (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one hydrochloride (1:1); (3aS)-2-((3S)-1-Azabicyclo[2.2.2]oct-3-yl)-2,3,3a,4,5,6-hexahydro-1H-benzo[de]isoquinolin-1-one Monohydrochloride; (3aS)-2,3,3a,4,5,6-Hexahydro-2-[(3S)-3-quinuclidinyl]-1H-benz[de]isoquinolin-1-one Monohydrochloride; Palonosetron (Hydrochloride)
- 用途
- 生命科学；一种抑制恶心呕吐药，属于新型高选择性、高亲和性5-HT3受体拮抗剂，用于预防和治疗化学疗法诱发的恶心和呕吐（CINV），可阻断呕吐反射中枢外周神经元的突触前5-HT受体兴奋，减少恶心呕吐发生率，能安全与皮质类固醇类、镇痛药等药物联用，不抑制五种化疗药物抗癌活性，是高效高选择性第二代5-HT3受体拮抗剂，血浆半衰期长约40小时。
