- 英文名称
- Pleuromutilin
- 分子式
- C22H34O5
- 分子量
- 378.5
- 中文别名
- 截断侧耳素; Mutilin 14-乙醇酸酯; 泰妙菌素; (3AS,4R,5S,6S,8R,9R,9AR,12R)-5-羟基-4,6,9,12-四甲基-1-氧代-6-乙烯基十氢-3A,9-丙环戊[8]-2-羟基乙酸8-基酯; PLEUROMULIN; PLEUROMUTILIN; Drosophilin B; Mutilin 14-glycolate; Valnemulin impurity E; glycolic acid,8-ester with octahydro-5,8-dihydroxy-4,6,9,10-tetramethyl-6-vinyl-3a,9-propano-3ah-cyclopentacycloocten-1(4h)-one; Acetic acid, 2-hydroxy-, 6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester; 5-Hydroxy-4,6,9,10-tetramethyl-1-oxo-6-vinyldecahydro-3a,9-propanocyclopenta[8]annulen-8-yl hydroxyacetate; 3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl glycolate
- 用途
- 作为截短侧耳素类药物半合成衍生物的前体，用于制备泰妙菌素、沃尼妙林、阿扎莫林和瑞他帕林等抗生素，其中泰妙菌素和沃尼妙林为动物专用药物，瑞他帕林为人用药物，用于治疗成人及9个月以上儿童因金黄色葡萄球菌和化脓链球菌引起的脓疱病，Lefamulin有望成为全身用药的人用截短侧耳素抗生素，用于治疗社区获得性细菌性肺炎。
