- 英文名称
- Scopine di(2-thienyl)glycolate
- 分子式
- C18H19NO4S2
- 分子量
- 377.48
- 中文别名
- 噻托溴铵EP杂质B; 2-(2-噻吩基)乙醇酸东莨菪酯; 噻托溴铵杂质B; 噻托溴铵一水合物EP杂质B; 噻托溴铵中间体2; Scopine-2,2-dithienyl glycolate; (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-7-yl 2-hydroxy-2,2-dithiophen-2-ylacetate; Tiotropium EP Impurity B; α-Hydroxy-α-2-thienyl-2-thiopheneacetic Acid (1α,2β,4β,5α,7β)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.02,4]non-7-yl Ester; Scopine Di(2-thienylglycolate); (1R,2R,4S,5S,7S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl hydroxy(dithiophen-2-yl)acetate; 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (1R,2R,4S,5S)-9-methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl ester; (1R,2R,4S,5S,7s)-9-Methyl-3-oxa-9-azatricyclo[3.3.1.0]non-7-yl hydroxy(di-2-thienyl)acetate; Scopine Di(2-thienyl) Glycolate
- 用途
- 主要用于合成噻托溴铵，可通过东莨菪醇与2,2-二(2-噻吩基)乙醇酸甲酯进行酯交换反应制得，最终经季铵盐化反应得到无水噻托溴铵；也可通过2,2-二(2-噻吩基)乙醇酸甲酯与东莨菪醇在金属钠或甲醇钠存在下于甲苯溶剂或无溶剂熔融状态下制得。
