路线1：以4-溴双环[2.2.2]辛烷-1-羧酸甲酯为原料
- 步骤：向含有677mg原料的反应瓶中加入65mL 10% NaOH水溶液；100℃油浴搅拌反应42小时；反应完成后浓缩至15mL，用30mL 1N HCl水溶液稀释；用12N HCl水溶液调节pH至1，EtOAc（5×70mL）萃取；合并有机相，无水MgSO4干燥，过滤浓缩得产物。
- 收率：89%
- 质谱：[MH]+ = 171
- 参考文献：
[1] Patent: WO2006/128184, 2006, A2. Location in patent: Page/Page column 174
[2] Journal of Organic Chemistry, 1970, vol. 35, p. 917 - 923
[3] Patent: US2010/267738, 2010, A1. Location in patent: Page/Page column 34
[4] Patent: WO2012/145569, 2012, A1. Location in patent: Page/Page column 136
[5] Patent: WO2015/5901, 2015, A1. Location in patent: Page/Page column 609
