770-12-7 二氯磷酸苯酯

运输信息：常温运输。危险描述：危险品运输编号UN 3265 8/PG 2，危险等级8，包装类别II，海关编码29209085，存储类别8A - 可燃，腐蚀性物质，危险性类别皮肤腐蚀类别1B，WGK Germany:3，RTECS号:TD4393000，F:10，TSCA:TSCA listed。非危险品（sinopharm_reagent_substance_v1）。

生命科学领域作为乙酰胆碱酯酶抑制剂；化学合成中用于制备磷酸二酯；用作二甲亚砜氧化反应的脱水剂；在生物农药甲氨基阿维菌素与兽药乙酰氨基阿维菌素的氧化物中间体合成中广泛应用；用于甲氨基阿维菌素苯甲酸盐的合成；用作亚磺酸与乙醇、氨、三醇等的偶联剂；用作甲氨基阿维菌素苯甲酸盐合成专用催化剂

医药; 农药; 化学合成

路线1：三氯氧磷与L-丙氨酸等反应

• 产率：98%
• 合成条件：With triethylamine; trichlorophosphate In tert-butyl methyl ether at -55 - 20℃; for 4 h;
• 实验步骤：将L-丙氨酸（25g，280.6mmol，1当量）悬浮于甲苯（700mL），对甲苯磺酸（58.7g，308.7mmol，1.1当量）和HDP-OH（169g，561.2mmol，2）中。加入等量的混合物，将得到的混合物加热回流，用Dean-Stark分离器过夜。将反应混合物真空蒸发。将粗固体在己烷中研磨，过滤并干燥，得到130g（85％收率）略微不纯的N，为甲苯磺酸盐。该物质无需进一步纯化即可使用。
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路线2：三氯氧磷与无水苯酚钠反应

• 方法：通过三氯氧磷与无水苯酚钠反应制备而来 (式1)。