913844-45-8 (S)-甘氨酰-H-1152 二盐酸盐

名称和标识

中文名: (S)-甘氨酰-H-1152 二盐酸盐
英文名: H-1152 Glycyl dihydrochloride
CAS号: 913844-45-8
分子式: C18H26Cl2N4O3S
分子量: 449.4
中文别名: (S)-甘氨酰-H-1152 盐酸盐; H-1152甘氨酰二盐酸盐
英文别名: (S)-2-Amino-1-(3-methyl-4-((4-methylisoquinolin-5-yl)sulfonyl)-1,4-diazepan-1-yl)ethanone dihydrochloride; (S)-Glycyl-H-1152 hydrochloride; (S)-(+)-4-Glycyl-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride; (2S)-4-(Aminoacetyl)hexahydro-2-methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepine Dihydrochloride; 2-Amino-1-{(3S)-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1,4-diazepan-1-yl}ethanone dihydrochloride; 2-Amino-1-[(3S)-hexahydro-3-methyl-4-[(4-methyl-5-isoquinolinyl)sulfonyl]-1H-1,4-diazepin-1-yl]ethanone Hydrochloride; Glycyl-H 1152 2HCl; Glycyl H-1152 hydrochloride; Rho Kinase Inhibitor IV

安全说明

运输方式为冰袋运输。危险性质：否。WGK Germany: WGK 1。存储类别: 11 - 可燃固体。

用途与制备

化学合成; 作为Rho-kinase抑制剂H-1152 dihydrochloride的糖基衍生物，抑制ROCKII、Aurora A、CAMKII和PKG，IC50值分别为0.0118、2.35、2.57和3.26μM，比H-1152 dihydrochloride具有更高的选择性

医药; 化学合成

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