7414-56-4 (((((((2R,3S,4R,5R)-5-(6-氨基-9H-嘌呤-9-基)-3,4-二羟基四氢呋喃-2-基)甲氧基)(羟基)磷酰基)氧基)羟基)磷酰基)甲基)膦酸二钠盐
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安全说明
干冰运输。WGK Germany:3。存储类别:6.1C - 可燃,急性毒性 类别3(经皮、吸入、经口),眼部刺激 类别2,经皮刺激 类别2,特异性靶器官毒性-一次接触,类别3。
用途与制备
AMP-PCP disodium是一种ATP类似物,可以以Kd值为3.8μM来结合到Hsp90的N末端结构域;AMP-PCP disodium结合有利于Hsp90活性同型二聚体的形成;AMP-PCP binding favors the formation of the active homodimer of Hsp90 by enhancing the slow-motion featured conformational exchanges of those residues (A117-A141) within the lid segment (A111-G135) and around region;In total, 170 non-proline residues are identified for the triple-labeled Hsp90 bound with AMP-PCP
生命科学