737763-37-0 360A 碘化物

危险性质：否

360A iodide是一种G-四联体(G-quadruplex)的稳定剂，同时可抑制端粒酶(telomerase)的活性，在TRAP-G4实验中，IC50值为300nM；360A iodide inhibits telomerase activity and stabilizes G-quadruplex, with an IC50 of 300nM for telomerase in TRAP-G4 assay. 360A reduces the viability of glioma cell lines, such as T98G, CB193, U118-MG, SAOS-2 and Primary astrocytes, with IC50s of 4.8 ± 1.1 μM, 3.9 ± 0.4 μM, 8.4 ± 0.5 μM, >15 μM and 17.4 ± 1.2 μM, respectively. 360A causes Rad51-dependent telomere aberrations preferentially involving the lagging strand telomeres, including telomere losses or telomere doublets, and induces DNA-PKcs-dependent sister telomere fusions.

生命科学