化学合成
化学合成
路线1：1,4-二氧杂螺[4.5]茚-7-烯-8-三氟甲磺酸酯与硼酸频哪醇酯反应
- 步骤：将1,4-二氧杂螺[4.5]茚-7-烯-8-三氟甲磺酸酯（500mg，1.73mmol）、1,4-二恶烷（8mL）、乙酸钾（260mg，2.64mmol）、硼酸频哪醇酯（530mg，2.08mmol）、Pd(dppf)Cl₂（130mg，0.17mmol）依次加入，氮气保护下110℃反应10小时；过滤、浓缩后经柱色谱（石油醚/乙酸乙酯=2/1）纯化，得540mg黄色油状物。
- 收率：99%
- 参考文献：
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