863239-60-5 甘醇奥贝胆酸

名称和标识

中文名: 甘醇奥贝胆酸
英文名: Glyco-Obeticholic acid
CAS号: 863239-60-5
分子式: C28H47NO5
分子量: 477.68
中文别名: 奥贝胆酸杂质8; 甘氨酰奥贝胆酸; 糖基奥贝胆酸; 糖基胆酸; 甘氨酸6-鹅脱氧胆酸乙酯
英文别名: N-[(3Α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]-glycine; Glyco Obeticholic acid; Obeticholic Acid Impurity 3; Glycine 6-Ethylchenodeoxycholate; ((R)-4-((3R,5S,6R,7R,8S,9S,10S,13R,14S,17R)-6-ethyl-3,7-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoyl)glycine; Glycine, N-[(3α,5β,6α,7α)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]-; Glycine, N-[(3a,5b,6a,7a)-6-ethyl-3,7-dihydroxy-24-oxocholan-24-yl]-; GlycoObeticholic acid

安全说明

危险性质：否

用途与制备

化学合成；作为牛磺酸的活性代谢物；是口服生物可利用的法尼样X受体(FXR)激动剂；在肝脏中由Obeticholic acid与甘氨酸结合形成，分泌入胆汁；在回肠和结肠中可被微生物去结合转化为母药Obeticholic acid，进而被重吸收或随粪便排泄

医药

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