4-(苄氧基)环己酮可用作医药合成中间体；如果吸入，将患者移到新鲜空气处；皮肤接触，脱去污染衣着，用肥皂水和清水彻底冲洗皮肤，如有不适感，就医；眼晴接触，分开眼睑，用流动清水或生理盐水冲洗，并立即就医；食入，立即漱口，禁止催吐，应立即就医。
医药
路线1：以1-乙烯缩醛-4-苄氧基-环己烷为原料
- 步骤：在室温下，向1-乙烯缩醛-4-苄氧基-环己烷（17）（3.13g，12.6mmol）的50ml THF溶液中加入盐酸水溶液（1N，30ml）。将反应物搅拌过夜，并用碳酸氢钠（饱和）中和。产物用乙酸乙酯萃取，有机相用盐水洗涤，硫酸钠干燥，过滤并浓缩。通过硅胶色谱法（20％乙酸乙酯的己烷溶液）纯化，得到2.45g标题酮。
- 条件：With hydrogenchloride In tetrahydrofuran; water at 20℃;
- 收率：95.2%
- 参考文献：[1] Tetrahedron Letters, 1999, vol. 40, # 9, p. 1799 - 1802 [2] Tetrahedron, 2003, vol. 59, # 45, p. 8989 - 8999 [3] Journal of the American Chemical Society, 2017, vol. 139, # 7, p. 2577 - 2580 [4] Patent: US2006/292073, 2006, A1. Location in patent: Page/Page column 12 [5] Canadian Journal of Chemistry, 2003, vol. 81, # 1, p. 81 - 108 [6] Journal of Organic Chemistry, 2011, vol. 76, # 19, p. 7706 - 7719 [7] New Journal of Chemistry, 2017, vol. 41, # 4, p. 1421 - 1424 [8] Angewandte Chemie - International Edition, 2016, vol. 55, # 5, p. 1816 - 1819 [9] Angew. Chem., 2016, vol. 128, # 5, p. 1848 - 1851,4 [10] Journal of the Chemical Society - Series Chemical Communications, 1984, vol. NO. 11, p. 721 - 723 [11] Journal of Organic Chemistry, 1982, vol. 47, # 20, p. 3881 - 3886 [12] Canadian Journal of Chemistry, 1994, vol. 72, # 7, p. 1699 - 1704 [13] Patent: US5808146, 1998, A [14] Patent: US5817776, 1998, A [15] Patent: WO2011/7146, 2011, A1. Location in patent: Page/Page column 61 [16] Patent: WO2012/151343, 2012, A1. Location in patent: Page/Page column 33 [17] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 8, p. 851 - 856 [18] Patent: WO2015/138220, 2015, A1. Location in patent: Page/Page column 78 [19] Patent: WO2017/205296, 2017, A1. Location in patent: Paragraph 532 [20] Patent: KR101905722, 2018, B1. Location in patent: Paragraph 0122; 0126
路线2：以1,4-二氧杂螺[4.5]癸烷-8-醇为原料
- 步骤：将60％的氢化钠在矿物油中的分散体（760mg，23mmol，1.2当量）加入到1,4-二氧杂螺[4.5]癸烷-8-醇（14-1）（3.0g，19mmol，1.0当量）在无水THF（50mL）中，0℃。6小时后，向混合物中加入苄基溴（2.5mL，21.3mmol，1.1当量）。将混合物在室温下搅拌过夜。加入4N HCl溶液（30mL）并将反应在室温下再搅拌6小时。用4N氢氧化钠将反应中和至pH~7，并用乙酸乙酯（3×100mL）萃取。将合并的有机层用硫酸钠干燥，过滤并减压浓缩。将残余物在AnaLogix自动柱色谱系统上纯化，用0至30％乙酸乙酯/庚烷的梯度洗脱，得到14-2。
- 条件：Stage #1: With sodium hydride In tetrahydrofuran; mineral oil at 0℃; for 6 h; Stage #2: at 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran; water; mineral oil at 20℃; for 6 h;
- 收率：77%
- 参考文献：[1] Patent: WO2012/151343, 2012, A1. Location in patent: Page/Page column 36 [2] Journal of Organic Chemistry, 1970, vol. 35, # 5, p. 1525 - 1534
