4282-77-3 9-(丙-2-炔-1-基)-9H-咔唑

运输信息：冰袋运输。危险描述：非危险化学品。

化学合成

化学合成

路线1：咔唑与3-溴丙炔合成法

• 原料：咔唑（4.175g，25mmol）、金属钠（0.575g，25mmol）、3-溴丙炔（3.38mL，39mmol）、1,4-二恶烷（20mL）、水、二氯甲烷（CH₂Cl₂）、无水硫酸钠（Na₂SO₄）、己烷/乙酸乙酯（10:1）
• 步骤：将咔唑和金属钠在二恶烷中于惰性气氛下回流至钠完全溶解；加入3-溴丙炔，冷却至室温搅拌18小时；加水后用二氯甲烷萃取；有机相用无水硫酸钠干燥、过滤；真空除溶剂，残余物经柱色谱（10:1己烷/乙酸乙酯）纯化
• 条件：Stage #1：惰性气氛、回流；Stage #2：20℃、18小时、惰性气氛
• 收率：76%
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