3485-62-9 克利溴铵

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名称和标识

中文名: 克利溴铵
英文名: Clidinium bromide
CAS号: 3485-62-9
分子式: C22H26BrNO3
分子量: 432.35
中文别名: 3-(2-羟基-2,2-二苯基乙酰氧基)-1-甲基奎宁-1-鎓溴化物; 溴奎环二苯酯; (1-甲基-1-氮杂双环[2.2.2]辛-8-基) 2-羟基-2,2-二苯基乙酸酯溴化物; 克利溴胺; 可立啶
英文别名: 3-(2-Hydroxy-2,2-diphenylacetoxy)-1-methylquinuclidin-1-ium bromide; 1-azoniabicyclo[2.2.2]octane, 3-[(hydroxydiphenylacetyl)oxy]-1-methyl-, bromide; 1-Methyl-3-benziloyloxyquinuclidinium Bromide; Ro 2-3773; 1-Azoniabicyclo[2.2.2]octane, 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-methyl-, bromide (1:1); 3-[2-Hydroxy(diphenyl)acetoxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide; 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane Bromide; 3-{[hydroxy(diphenyl)acetyl]oxy}-1-methyl-1-azoniabicyclo[2.2.2]octane bromide; (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) 2-hydroxy-2,2-diphenylacetate,bromide; Clidinium (bromide); CLIDINIUM BROMIDE; 3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE; 3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE; QUARZAN; RO-2-3773; quinuclidinolmethylbromide,benzilate; 3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane Bromide, Ro-2-3773, Quarzan; Clidinium

安全说明

运输信息：常温运输。危险描述：非危险化学品（但危险品运输编号3249，危险等级6.1(b)，包装类别III，海关编码2933399090，存储类别11 - 可燃固体，RTECS号VD6125000，WGK Germany:3，危险性类别急性毒性类别4 经口）

用途与制备

化学合成，医药中间体；作为季胺抗毒蕈碱剂，通过减少胃酸和减慢肠道速度缓解痉挛和腹部/胃疼的症状；在小鼠体内研究中，0.25、0.5和1 mg/kg剂量经口灌胃3天，可引起便秘、显著降低结肠转运率及戊四氮诱导的阵挛性惊厥阈值。

医药