33529-02-1 1-癸基-1H-咪唑

运输信息：常温运输。危险描述：非危险化学品。

化学合成

化学合成

路线1：微波辅助法

• 步骤：在宽颈锥形瓶中引入6.8g（0.1mol）咪唑，45.5g（0.1mol）1-溴十六烷，2.4g（7.5mmol）叔丁基溴化铵（TBAB）；将混合物吸附在碳酸钾和氢氧化钾的比例为1：1的混合物上，然后在家用微波炉中的开口容器中以300瓦的功率照射3分钟，持续20秒，然后变为糊状；在二氯甲烷中稀释后，用水洗涤，分离有机相并用硫酸钠干燥；过滤后，在真空下蒸发溶剂。
• 条件：50℃；家用微波炉，300瓦功率间歇照射（每次20秒，共3分钟）。
• 收率：94%
• 参考文献：[1] Journal of Materials Chemistry, 2011, vol. 21, # 33, p. 12280 - 12287；[2] Oriental Journal of Chemistry, 2015, vol. 31, # 4, p. 2391 - 2394；[3] Patent: CN103951702, 2016, B. Location in patent: Paragraph 0049; 0050；[4] Polymer, 2014, vol. 55, # 26, p. 6664 - 6671；[5] New Journal of Chemistry, 2007, vol. 31, # 6, p. 879 - 892；[6] Journal of Surfactants and Detergents, 2016, vol. 19, # 4, p. 681 - 691；[7] European Journal of Inorganic Chemistry, 2015, vol. 2015, # 3, p. 408 - 413；[8] Polyhedron, 2017, vol. 127, p. 68 - 83；[9] Russian Journal of Applied Chemistry, 1996, vol. 69, # 12, p. 1841 - 1848；[10] Organic Letters, 2009, vol. 11, # 8, p. 1757 - 1759；[11] Synthesis, 2009, # 19, p. 3219 - 3226；[12] Organic Letters, 2010, vol. 12, # 21, p. 4988 - 4991；[13] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 17, p. 2863 - 2865；[14] Polish Journal of Chemistry, 1995, vol. 69, # 3, p. 447 - 460；[15] Chemistry Letters, 2005, vol. 34, # 3, p. 442 - 443；[16] Journal of Chemical and Engineering Data, 2006, vol. 51, # 4, p. 1274 - 1279；[17] Electrochimica Acta, 2010, vol. 55, # 20, p. 5652 - 5658；[18] Physical Chemistry Chemical Physics, 2011, vol. 13, # 6, p. 2062 - 2068；[19] Dyes and Pigments, 2013, vol. 96, # 1, p. 16 - 24,9；[20] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 4, p. 423 - 427；[21] Journal of the Chinese Chemical Society, 2013, vol. 60, # 7, p. 745 - 754；[22] Chemical Biology and Drug Design, 2014, vol. 83, # 3, p. 278 - 288；[23] RSC Advances, 2015, vol. 5, # 4, p. 2869 - 2881；[24] RSC Advances, 2015, vol. 5, # 71, p. 57968 - 57974；[25] Langmuir, 2015, vol. 31, # 12, p. 3587 - 3595；[26] RSC Advances, 2015, vol. 5, # 28, p. 21865 - 21876；[27] Molecules, 2018, vol. 23, # 9,

路线2：丙酮回流法

• 步骤：将咪唑（100mmol），烷基溴（100mmol）和K₂CO₃（200mmol）丙酮（200mL）的混合物回流过夜；过滤并除去溶剂后，将剩余的残余物用乙酸乙酯进行快速色谱。
• 条件：碳酸钾存在下，在丙酮中回流。
• 收率：70%
• 参考文献：[1] Molecules, 2018, vol. 23, # 9,