2303-35-7 氯化毒蝇碱

运输信息：冰袋运输。危险描述：剧毒（UN 2811 6.1/PG 2），急性毒性类别1（吸入）、类别2（经皮、经口），严重眼刺激（类别2）。高毒性，吸入、皮肤吸收、摄入致命。症状包括出汗、流涎、视力障碍、恶心、呕吐、腹痛、腹泻、头痛、支气管痉挛，高剂量可致流泪、失禁、心动过缓、低血压、休克。存储类别6.1A，WGK Germany 3。

Muscarine is an alkaloid found in red Amanita muscaria and other fungi; used as a cholinergic drug strictly for research purposes. It has no clinical uses. Only the naturally occurring L-(+)-form exhibits cholinomimetic activity. It is a trace compound in Amanita muscaria, with muscimol being the pharmacologically more relevant compound. It has been found in trace amounts in Entoloma, Mycena, Boletus, Hygrocybe, Lactarius, and Russula mushrooms. Acute toxicity: intravenous LD50 in mice is 0.23 mg/kg. Combustible, emits nitrogen oxides and chloride pungent smoke in fire. Store in ventilated, low-temperature, dry warehouses; separate from acids and food. Fire extinguishing agents: water, sand.

生命科学研究; 实验研究

路线1：经典外消旋体合成

• 文献来源: KOGL ET AL, REC TRAV CHIM 76, 109 (1957); KOGL ET AL, EXPERIENTIA 13, 137 (1957); COX ET AL, HELV CHIM ACTA 41, 229 (1958)
• 路线2：替代合成方法
• 文献来源: BRITISH PATENT 828,395 (1960 TO HOFFMAN-LA ROCHE); MATSUMOTO ET AL, TETRAHEDRON 25, 5889 (1969); WC STILL, JA SCHNEIDER, J ORG CHEM 45, 3375 (1980)
• Muscarine合成
• 文献来源: WHITING ET AL, CAN J CHEM 50, 3322 (1972); AM MUBARAK, DM BROWN, TETRAHEDRON LETTERS 21, 2453 (1980); J CHEM SOC PERKIN TRANS I 1982, 809; S POCHET, T HUYNHDINH, J ORG CHEM 47, 193 (1982)