2138300-40-8 1,1'-(丁烷-1,4-二基)双(2-(1-乙基-3-甲基-1H-吡唑-5-甲酰胺)-1H-苯并[d]咪唑-5-甲酰胺)

中文名称: 1,1'-(丁烷-1,4-二基)双(2-(1-乙基-3-甲基-1H-吡唑-5-甲酰胺)-1H-苯并[d]咪唑-5-甲酰胺)
英文名称: 1,1'-(Butane-1,4-diyl)bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)
CAS号
分子式: C₃₄H₃₈N₁₂O₄
分子量: 678.74
更新日期: 2026-06-23

名称和标识

中文名: 1,1'-(丁烷-1,4-二基)双(2-(1-乙基-3-甲基-1H-吡唑-5-甲酰胺)-1H-苯并[d]咪唑-5-甲酰胺)
英文名: 1,1'-(Butane-1,4-diyl)bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)
CAS号: 2138300-40-8
分子式: C34H38N12O4
分子量: 678.74
中文别名: STING激动剂-4
英文别名: STING agonist-4; STING agonist 2; diABZI STING agonist-2; STING agonist diABZI compound 2; 1-[4-[5-carbamoyl-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazol-1-yl]butyl]-2-[(2-ethyl-5-methylpyrazole-3-carbonyl)amino]benzimidazole-5-carboxamide; 1-(4-(5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl)butyl)-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide; 1-{4-[5-carbamoyl-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazol-1-yl]butyl}-2-(1-ethyl-3-methyl-1H-pyrazole-5-amido)-1H-1,3-benzodiazole-5-carboxamide; 1,1'-(1,4-butanediyl)bis[2-[[(1-ethyl-3-methyl-1H-pyrazol-5-yl)carbonyl]amino]-1H-benzimidazole-5-carboxamide; 1,1'-(butane-1,4-diyl)bis{2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1H-benzimidazole-5-carboxamide}; 1-[4-[5-carbamoyl-2-[(2-ethyl-5-methyl-pyrazole-3-carbonyl)amino]benzimidazol-1-yl]butyl]-2-[(2-ethyl-5-methyl-pyrazole-3-carbonyl)amino]benzimidazole-5-carboxamide; HG4

用途与制备

作为STING受体激动剂，用于体外研究中诱导IRF3和STING磷酸化，促进IFN-β分泌，以及抑制STING与配体结合，其EC50为3.1 μM，比cGAMP更具效力（18倍），可用于研究STING介导的免疫反应机制。

医药

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2138300-40-8 1,1'-(丁烷-1,4-二基)双(2-(1-乙基-3-甲基-1H-吡唑-5-甲酰胺)-1H-苯并[d]咪唑-5-甲酰胺)

中文名称

1,1'-(丁烷-1,4-二基)双(2-(1-乙基-3-甲基-1H-吡唑-5-甲酰胺)-1H-苯并[d]咪唑-5-甲酰胺)

英文名称

1,1'-(Butane-1,4-diyl)bis(2-(1-ethyl-3-methyl-1H-pyrazole-5-carboxamido)-1H-benzo[d]imidazole-5-carboxamide)

CAS号

分子式

C₃₄H₃₈N₁₂O₄

分子量

678.74

更新日期

2026-06-23