1445385-02-3 卢米西他滨

名称和标识

中文名: 卢米西他滨
英文名: Lumicitabine
CAS号: 1445385-02-3
分子式: C18H25ClFN3O6
分子量: 433.86
中文别名: ALS-8176
英文别名: Als-8176; ALS-008176; ALS8176; ALS 8176; lumicitabina; lumicitabinum; 4-Amino-1-{5-chloro-2,5-dideoxy-2-fluoro-3-O-isobutyryl-4-[(isobutyryloxy)methyl]-α-L-lyxofuranosyl}-2(1H)-pyrimidinone; 4'-C-(chloromethyl)-2'-deoxy-2'-fluorocytidine 3',5'-bis(2-methylpropanoate); 4'-Chloromethyl-2'-deoxy-3',5'-di-o-isobutyryl-2'-fluorocytidine; Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-, 3',5'-bis(2-methylpropanoate); [(2R,3R,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-2-(chloromethyl)-4-fluoro-3-[(2-methylpropanoyl)oxy]oxolan-2-yl]methyl 2-methylpropanoate; ((2R,3R,4R,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)-2-(chloromethyl)-4-fluoro-3-((2-methylpropanoyl)oxy)oxolan-2-yl)methyl 2-methylpropanoate; [(2R,3R,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-(chloromethyl)-4-fluoro-3-(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate; 4'-C-(Chloromethyl)-2'-deoxy-2'-fluoro-cytidine 3',5'-Bis(2-methylpropanoate); (2R,3R,4R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-2-(chloromethyl)-4-fluoro-2-((isobutyryloxy)methyl)tetrahydrofuran-3-yl Isobutyrate; [(2R,3R,4R,5R)-5-(4-amino-2-oxo-pyrimidin-1-yl)-2-(chloromethyl)-4-fluoro-3-(2-methylpropanoyloxy)tetrahydrofuran-2-yl]methyl 2-methylpropanoate

安全说明

运输方式：冰袋运输。危险描述：非危险化学品（但根据GHS分类，具有生殖毒性，类别2，H361，需注意防护）。防护措施：P203（避免混合）、P280（戴防护手套/护目镜）、P318（紧急就医）、P405（储存于干燥处）、P501（按规定处理）。

用途与制备

化学合成；Lumicitabine (ALS-008176) 是呼吸道合胞病毒（RSV）聚合酶的抑制剂。

医药

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