144313-54-2 缬啡肽

中文名称: 缬啡肽
英文名称: Valorphin
CAS号
分子式: C₄₄H₆₁N₉O₁₁
分子量: 892.02
更新日期: 2026-06-23

名称和标识

中文名: 缬啡肽
英文名: Valorphin
CAS号: 144313-54-2
分子式: C44H61N9O11
分子量: 892.02
中文别名: 化合物Valorphin; VAL-VAL-TYR-PRO-TRP-THR-GLN
英文别名: VALORPHIN; VAL-VAL-TYR-PRO-TRP-THR-GLN; H-Val-Val-Tyr-Pro-Trp-Thr-Gln-OH; H-VVYPWTQ-OH; (2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-hydroxybutanoyl]amino]pentanedioic acid; L-Glutamine, L-valyl-L-valyl-L-tyrosyl-L-prolyl-L-tryptophyl-L-threonyl-

物化属性

Exact Mass: 892.43306938 Da
Monoisotopic Mass: 892.43306938 Da
XLogP3: -0.8
储存条件: -15°C
分子量: 893.0 g/mol
密度: 1.330±0.06 g/cm³ (Predicted)
拓扑极性表面积: 323 Å²
沸点: 1364.0±65.0 °C (Predicted)
溶解度: 溶于二甲基亚砜
酸度系数(pKa): 3.21±0.10 (Predicted)

安全信息

安全说明

运输信息：冰袋运输。危险描述：非危险化学品。

生产及用途

用途与制备

Valorphin is used as a pharmaceutical agent with opioid analgesic activity (binds to mu-opioid receptor, IC50 14 nM; also binds δ-opioid receptor with IC50 200 nM, no κ receptor affinity). It exhibits analgesic activity in mice, rats, and rhesus monkeys (ED50 ≤5.2 mg/kg s.c.), and antitumor activity (100% tumor cell death in vitro with epirubicin/vincristine; 42% tumor growth inhibition in vivo).

医药

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