188404-10-6 ((5Z,8Z,11Z,14Z)-二十碳-5,8,11,14-四烯-1-基)氟磷酸甲酯

运输信息：冰袋运输。危险描述：危险品运输编号UN 1231 3/PG 2，WGK Germany 1，存储类别3-易燃液体，危险性类别为眼部刺激类别2、易燃液体类别2、特异性靶器官毒性-一次接触类别3。

MAFP is a selective, irreversible inhibitor of cPLA2 and iPLA2; it is also an effective irreversible anandamide amidase inhibitor and a ligand for the CB1 cannabinoid receptor. In vitro, it inhibits iPLA2 with an IC50 of 5 μM in P388D1 cells after 5 min preincubation at 40°C, and shows selectivity for anandamide amidase (3000 and 30000-fold more potent than chymotrypsin and trypsin, respectively), and displaces [3H]CP-55940 binding to CB1 with an IC50 of 20 nM (vs 40 nM for anandamide).

医药