185955-34-4 3-O-癸基-2-脱氧-6-O-[2-脱氧-3-O-[(3R)-3-甲氧基癸基]-6-O-甲基-2-[[(11Z)-1-氧代-11-十八烯基]氨基]-4-O-磷酰基-beta-D-吡喃葡萄糖基]-2-[(1,3-二氧代十四烷基)氨基]-alpha-D-吡喃葡萄糖 1-(二氢磷酸)

名称和标识

中文名: 3-O-癸基-2-脱氧-6-O-[2-脱氧-3-O-[(3R)-3-甲氧基癸基]-6-O-甲基-2-[[(11Z)-1-氧代-11-十八烯基]氨基]-4-O-磷酰基-beta-D-吡喃葡萄糖基]-2-[(1,3-二氧代十四烷基)氨基]-alpha-D-吡喃葡萄糖 1-(二氢磷酸)
英文名: Eritoran
CAS号: 185955-34-4
分子式: C66H126N2O19P2
分子量: 1313.66
中文别名: 依立托仑; 3-O-癸基-2-脱氧-6-O-[2-脱氧-3-O-[(3R)-3-甲氧基癸基]-6-O-甲基-2-[[(11Z)-1-氧代-11-十八烯基]氨基]-4-O-磷酰基-BETA-D-吡喃葡萄糖基]-2-[(1,3-二氧代十四烷基)氨基]-ALPHA-D-吡喃葡萄糖
英文别名: Eritoran [INN]; E5564; 3-O-Decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecenyl]amino]-4-O-phosphono-beta-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate); α-D-Glucopyranose, 3-O-decyl-2-deoxy-6-O-[2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[[(11Z)-1-oxo-11-octadecen-1-yl]amino]-4-O-phosphono-β-D-glucopyranosyl]-2-[(1,3-dioxotetradecyl)amino]-, 1-(dihydrogen phosphate); [(2R,3R,4R,5S,6R)-4-decoxy-5-hydroxy-6-[[(2R,3R,4R,5S,6R)-4-[(3R)-3-methoxydecoxy]-6-(methoxymethyl)-3-[[(Z)-octadec-11-enoyl]amino]-5-phosphonooxyoxan-2-yl]oxymethyl]-3-(3-oxotetradecanoylamino)oxan-2-yl] dihydrogen phosphate; eritoranum; 3-O-decyl-2-deoxy-6-O-(2-deoxy-3-O-(3-methoxydecyl)-6-O-methyl-2-((1-oxo-11-octadecenyl)amino)-4-O-phosphonoglucopyranosyl)-2-((1,3-dioxotetradecyl)amino)-1-(dihydroxy phosphate)glucopyranose; 3-O-decyl-2-deoxy-6-O-{2-deoxy-3-O-[(3R)-3-methoxydecyl]-6-O-methyl-2-[(11Z)-octadec-11-enamido]-4-O-phosphono-beta-D-glucopyranosyl}-2-(3-oxotetradecanamido)-1-O-phosphono-alpha-D-glucopyranose

物化属性

LogP: 16.14580
PSA: 324.57000
XLogP3-AA: 15.4
分子量: 1313.7 g/mol
密度: 1.14
拓扑极性表面积

生产及用途

用途与制备

作为Toll样受体4 (TLR4) 拮抗剂，用于保护小鼠免受致命流感病毒（如埃博拉病毒、马尔堡病毒）感染；降低粒细胞增多水平以减轻“细胞因子风暴”；抑制丝状病毒感染发病机制；具有抗炎活性。

医药