1820565-69-2 N-(4-((1R,3S,5S)-3-氨基-5-甲基环己基)吡啶-3-基)-6-(2,6-二氟苯基)-5-氟吡啶酰胺二盐酸盐

运输信息：冰袋运输。危险描述：非危险化学品。

PIM447 dihydrochloride is a selective pan-PIM kinase inhibitor for treating multiple myeloma (MM). It inhibits MM cell viability (IC50 0.2-3.3 µM in sensitive lines), induces apoptosis via caspase cleavage and PARP cleavage, arrests cell cycle in G0/G1 phase, and controls tumor progression with bone protective effects in NSG mice (oral gavage, 100 mg/kg, 5x/week).

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