176655-55-3 去噻唑基甲氧羰基利托那韦

中文名称: 去噻唑基甲氧羰基利托那韦
英文名称: Desthiazolylmethyloxycarbonyl Ritonavir
CAS号
分子式: C₃₂H₄₅N₅O₃S
分子量: 579.8
更新日期: 2026-06-23

名称和标识

中文名: 去噻唑基甲氧羰基利托那韦
英文名: Desthiazolylmethyloxycarbonyl Ritonavir
CAS号: 176655-55-3
分子式: C32H45N5O3S
分子量: 579.8
中文别名: 利托那韦代谢物; 哒嗪基甲氧基羰基利托那韦; 利托那韦杂质27; 利托那韦杂质39
英文别名: Ritonavir metabolite; Ritonavir metabolite M1; A-98498; (2S)-N-[(2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanamide; (2S)-N-[(1S,3S,4S)-4-amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]butanamide; Butanamide, N-[(1S,3S,4S)-4-amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]-3-methyl-2-[[[methyl[[2-(1-methylethyl)-4-thiazolyl]methyl]amino]carbonyl]amino]-, (2S)-; Ritonavir metabolite Desthiazolylmethyloxycarbonyl Ritonavir; Ritonavir Impurity 27; Ritonavir Impurity 39; (2S)-N-((1S,3S,4S)-4-Amino-1-benzyl-3-hydroxy-5-phenyl-pentyl)-2-(((2-isopropylthiazol-4-yl)methyl-methyl-carbamoyl)amino)-3-methyl-butanamide; Butanamide, N-((1S,3S,4S)-4-amino-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl)-3-methyl-2-(((methyl((2-(1-methylethyl)-4-thiazolyl)methyl)amino)carbonyl)amino)-, (2S)-; (2S)-N-[(1S,3S,4S)-4-amino-1-benzyl-3-hydroxy-5-phenyl-pentyl]-2-[[(2-isopropylthiazol-4-yl)methyl-methyl-carbamoyl]amino]-3-methyl-butanamide; N-[(2s,4s,5s)-5-Amino-4-Hydroxy-1,6-Diphenylhexan-2-Yl]-N~2~-(Methyl{[2-(Propan-2-Yl)-1,3-Thiazol-4-Yl]methyl}carbamoyl)-L-Valinamide; (S)-N-((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanamide

物化属性

LogP: 6.22600
PSA: 155.80000 Å²
XLogP3-AA: 4.8
分子量: 579.8 g/mol
外观性质: 白色至浅棕色固体
折射率: 1.587
沸点: 822.431ºC (760 mmHg)
溶解度: 可溶于氯仿（少量）、二氯甲烷（少量）、DMSO（少量）、乙酸乙酯
熔点: 73-74°C
精确质量: 579.32431149 Da
蒸汽压: 0 mmHg (25°C)
闪点: 451.19ºC

生产及用途

用途与制备

Ritonavir metabolite 是抗病毒抑制剂 Ritonavir 的代谢物，用于相关抗病毒研究与药物代谢分析。

医药

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