171746-21-7 4-[2-[5,6-二氢-5,5-二甲基-8-(4-甲基苯基)-2-萘基]乙炔基]苯甲酸
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安全说明
干冰运输,危险性质:非危险化学品。WGK Germany: WGK 3,存储类别: 11 - 可燃固体
用途与制备
AGN 193109 is a retinoic acid analog, a highly effective and specific antagonist of retinoic acid receptors (RARs), inhibiting RARα, RARβ, and RARγ with Kd values of 2 nM, 2 nM, and 3 nM respectively. It is used in life sciences research, with in vitro studies showing inhibition of TTNPB-induced morphological changes and growth suppression in ECE16-1 cells, and in vivo studies demonstrating suppression of TTNPB-induced spleen weight increase and reduction of cutaneous toxicity from ATRA and TTNPB.
医药