16662-47-8 戈洛帕米

名称和标识

中文名: 戈洛帕米
英文名: Gallopamil
CAS号: 16662-47-8
分子式: C28H40N2O5·HCl
分子量: 521.09
中文别名: (±)-α-[3-[(2-(3,4-二甲氧基苯基)乙基)甲氨基]丙基]-3,4,5-三甲氧基-α-(1-甲基乙基)苯乙腈盐酸盐; (±)-甲氧基维拉帕米盐酸盐; 戈洛帕米盐酸盐; 甲氧戊脉安; (±)-甲氧基维拉帕米盐酸盐; (±)-甲氧基维拉帕米
英文别名: 5-[(3,4-Dimethoxyphenethyl)methylamino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)valeronitrile; 5-[[2-(3,4-Dimethoxyphenyl)ethyl](methyl)amino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile; Methoxyverapamil; 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile; 5-((3,4-Dimethoxyphenethyl)(methyl)amino)-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile HCl; Compound D 600; D 600 (vasodilator); 5-[2-(3,4-dimethoxyphenyl)ethyl-methylamino]-2-propan-2-yl-2-(3,4,5-trimethoxyphenyl)pentanenitrile; Galopamilo; Gallopamillum; D600; D-600; LU-30-029; Benzeneacetonitrile, alpha-(3-((2-(3,4-dimethoxyphenyl)ethyl)methylamino)propyl)-3,4,5-trimethoxy-alpha-(1-methylethyl)-; 5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-isopropyl-2-(3,4,5-trimethoxyphenyl)pentanenitrile; Elgiprona; (+-)-Gallopamil; Gallopamil hydrochloride; (+/-)-Methoxyverapamil; (+/-)-Methoxyverapamil hydrochloride

安全说明

运输方式为冰袋运输。危险性质：非危险化学品。WGK Germany:3，存储类别为11 - 可燃固体。

用途与制备

生命科学；作为钙拮抗剂，抑制酸分泌（IC50 10.9 μM），有效抗心律不齐和血管扩张；德国2009年用量>100kg，人均消费0.00122g，计算去除率18.8%；动物实验中静脉注射0.2mg/kg可减少室性心动过速并预防心室颤动，显著降低血压但对心率影响小。

医药

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