159432-28-7 (2R,5S,8S,11S,14S,17S,20S)-5-((1H-咪唑-4-基)甲基)-20-氨基-8-((S)-仲丁基)-17-(3-胍基丙基)-11-(4-羟基苄基)-14-异丙基-2-甲基-4,7,10,13,16,19-六氧代-3,6,9,12,15,18-六氮杂二十二烷二酸
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安全说明
运输方式:冰袋运输。危险性质:非危险化学品。WGK Germany: WGK 3。海关编码: 2933.29.4300。存储类别: 11 - 可燃固体。
用途与制备
A 779 is a G protein-coupled receptor Mas antagonist (Ang1-7 receptor). In vitro: inhibits Ang-(1-7) effects on PCNA, VSMC proliferation/migration, and inflammatory responses (MCP-1, VCAM-1, IL-1β). In vivo: elevates bone markers (BALP, CTX, TRAcP 5b, OC, DPD) in OVX rats; blocks captopril's bone protective effects and Ang1-7/Mas pathway downregulation.
医药