1259330-61-4 三棱内酯B

运输方式：冰袋运输。危险性质：非危险化学品。GHS分类：皮肤刺激类别2（H315）、严重眼刺激类别2（H319）。防护措施：P264、P264+P265、P280、P302+P352、P305+P351+P338、P321、P332+P317、P337+P317、P362+P364。存储类别：11 - 可燃固体。WGK Germany：3。

Sparstolonin B is a selective TLR2 and TLR4 antagonist, blocking TLR2/TLR4-mediated inflammatory signaling. It has anti-HIV and anticancer activities. In vitro, it inhibits neuroblastoma cell growth (SH-SY5Y, IMR-32, NGP, SKNF-1, SK-N-BE(2) cells) at 1-20 µM for 2-4 days, and reduces N-myc expression and ROS generation. In vivo, 100 µg/mouse i.p. suppresses LPS-induced inflammation in C57Bl/6 mice, lowering TNFα and IL-1β.

生命科学; 医药