112559-91-8 羟基伊曲康唑

运输方式：冰袋运输。危险描述：WGK Germany:WGK 1；存储类别:3- 易燃液体；危险性类别:急性毒性 类别3（经皮、吸入、经口）；易燃液体 类别2；特异性靶器官毒性-一次接触类别1。

Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), a triazole antifungal agent. It has antifungal activity in vitro and in vivo, inhibits CYP3A, and its half-lives can be extended by 26-60% with repeated administration compared to single administration. Plasma concentration is weakly dependent on ITZ dose (likely due to saturation of formation process), influenced by serum albumin and GFR. Antifungal activity should consider both ITZ and Hydroxy Itraconazole plasma concentrations, with similar pharmacokinetics to ITZ in immunocompromised patients on ITZ oral solution.

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