33627-41-7 旋覆花内酯

中文名称: 旋覆花内酯
英文名称: Inulicin
CAS号
分子式: C₁₇H₂₄O₅
分子量: 308.37
更新日期: 2026-06-23

名称和标识

中文名: 旋覆花内酯
英文名: Inulicin
CAS号: 33627-41-7
分子式: C17H24O5
分子量: 308.37
中文别名: (S)-4-((3aS,4S,7aR)-4-羟基-6-甲基-3-亚甲基-2-氧代-2,3,3a,4,7,7a-六氢苯并呋喃-5-基)戊基乙酸酯; 旋复花内酯; 旋覆花次内酯; 旋覆花素; 1-O-乙酰基大花旋覆花内酯; 乙酰旋覆花内酯
英文别名: (S)-4-((3aS,4S,7aR)-4-Hydroxy-6-methyl-3-methylene-2-oxo-2,3,3a,4,7,7a-hexahydrobenzofuran-5-yl)pentyl acetate; 6-(3-acetoxy-propyl)-4-hydroxy-5,7-dimethyl-3-methylene-3,3a,4,5,8,8a-hexahydro-cyclohepta[b]furan-2-one; 3-(4-Hydroxy-5,7-dimethyl-3-methylene-2-oxo-3,3a,4,5,8,8a-hexahydro-2H-cyclohepta[b]furan-6-yl)propyl acetate; Britannilactone; 1-O-Acetylbritannilactone; (3aS)-3,3aα,4,5,8,8aα-Hexahydro-4α-hydroxy-6-(3-acetoxypropyl)-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one; (3aS)-6-(3-Acetoxypropyl)-3,3aα,4,5,8,8aα-hexahydro-4α-hydroxy-5α,7-dimethyl-3-methylene-2H-cyclohepta[b]furan-2-one; (3aS,4S,7aR)-5-[(1S)-4-(Acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-2(3H)-benzofuranone; 1-O-Acetylbritannilactone (Inulicin); 2(3H)-Benzofuranone,5-[(1S)-4-(acetyloxy)-1-methylbutyl]-3a,4,7,7a-tetrahydro-4-hydroxy-6-methyl-3-methylene-,(3aS,4S,7aR)-

物化属性

LogP: 2.12
PSA: 72.83
外观: 白色至类白色粉末或固体
密度: 1.2±0.1 g/cm³
折射率: 1.521
沸点: 483.1±45.0 °C (760 mmHg)
溶解度: 可溶于甲醇、乙醇、二甲亚砜等有机溶剂，可溶于DMSO
熔点: 124.0-126.1 °C
精确质量: 308.162384
蒸汽压: 0.0±2.8 mmHg (25°C)
酸度系数(pKa): 13.71±0.60 (Predicted)
闪点: 173.1±22.2 °C

安全信息

安全说明

干冰运输，非危险化学品。WGK Germany:3，存储类别11 - 可燃固体，危险性类别急性毒性类别4（经口）。

生产及用途

用途与制备

Inulicin (1-O-Acetylbritannilactone) is isolated from Inula Britannica L. It inhibits VEGF-mediated Src and FAK activation, angiogenesis, and lung cancer cell growth (A549) in vitro and in vivo (xenograft model). It also suppresses LPS-induced PGE2 production, COX-2 expression, and NF-κB activation in vascular smooth muscle cells.

生命科学；中草药成分；医药（抗肿瘤、抗炎）

提取分离路线

来源: Inula britannica-F.
提取方法: 从Inula britannica中分离纯化得到Inulicin (1-O-Acetylbritannilactone)。
备注: 具体提取工艺未在提供的资料中详细说明，仅提及该化合物的分离来源。

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