13224-84-5 5-(三甲基硅烷基)-4-戊炔-1-醇

运输方式：冰袋运输。危险描述：非危险化学品，危险品运输编号1987，WGK Germany:3，海关编码29310099，存储类别10 - 可燃性液体。

作为有机合成中的重要中间体，用于构建复杂有机分子结构，在医药、农药等领域的合成反应中发挥作用。

有机合成中间体

合成路线 1（1. 合成：13224-84-5）

• 步骤: 在-78℃下滴加4-戊炔-1-醇（5.9g，70mmol，1.0当量）的THF（100mL）溶液中的正丁基锂（2.50M的己烷溶液，60.0mL，147mmol，2.10当量）；将混合物缓慢温热至室温，再次冷却至-78℃；滴加新蒸馏的TMSCl（20.0mL，154mmol，2.20当量），温热至室温搅拌2小时；用3M HCl水溶液淬灭，剧烈搅拌3小时；水层用Et₂O萃取两次，合并有机萃取液用盐水洗涤，无水MgSO₄干燥，过滤并蒸发得到产物。
• 条件: 反应在THF和己烷混合溶剂中进行，分阶段控温（-78℃→室温→-78℃→室温），惰性气氛保护，淬灭后搅拌3小时。
• 收率: 100%
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