体外研究
Dolastatin 10 is a unique pentapeptide that isolated from the sea hare
Dolabella auricularia
. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI
50
values of 10
−5
-10
−6
μg/mL (10
−2
-10
−3
nM) against a similar minipanel of human cell lines. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10.
