化学合成。
化学合成
合成路线 1（1. 合成：76360-43-5）
产率：100%
合成条件：Reflux
实验步骤：用硫酸（2.5mL，45mmol）处理2-溴-3-噻吩甲酸（10.1g，49mmol）的MeOH（100mL）溶液。 将反应加热至回流过夜。 减压浓缩混合物以除去有机溶剂，并将所得混合物倒入冰冷的水中。 用EtOAc萃取冷溶液。 用水洗涤合并的有机萃取物，然后用饱和碳酸氢钠水溶液洗涤。 用无水硫酸钠干燥有机溶液，过滤并减压浓缩滤液，得到标题化合物10.77g（100％）。 1H NMR（400.15MHz，DMSO-d6）δ7.65（d，J = 6Hz，1H），7.34（d，J = 6Hz，1H），3.78（s，3H）。
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