用于医药相关研究与制备,具体用途需参考相关文献。
医药
合成路线 1(1. 合成:81787-62-4)
产率:87%
合成条件:With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine In tetrahydrofuran at 20℃; for 4 h; Inert atmosphere
实验步骤:通用方法:在氩气氛下,向2-碘代芳烃1(1mmol)的无水THF / Et 3 N(2:1,10mL)溶液中加入Pd(PPh 3)2 Cl 2(0.025mmol)和CuI(0.05mmol)。 然后滴加三甲基甲硅烷基乙炔2(1.3mmol),将得到的混合物在室温下搅拌4小时(TLC)。 减压浓缩反应混合物,残余物用硅胶(100-200目)柱色谱法纯化,用二乙醚石油醚(4-10%)洗脱,得到纯的 - ((三甲基甲硅烷基)乙炔基)芳烃3,产率良好( 表格1)。
参考文献:
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