300657-03-8 2-(5-乙基-3,4-二苯基-吡唑-1-基)-联苯-3-基氧基]乙酸

危险性质：非危险化学品

• 生物活性 BMS309403是FABP4小分子抑制剂，Kd值为4 nM，对FABP4的选择性比对FABP5和FABP3高100倍以上。
• 靶点 Target Value FABP4 (Cell-free assay) 4 nM(Kd)
• 体外研究 Treatment with BMS-309403 significantly decreased MCP-1 production from THP-1 macrophages in a dose- and time-dependent manner.
• 体内研究 BMS-309403 sodium (15 mg/kg; chronic treatment; daily for 6 weeks) improves endothelial function, phosphorylated and total eNOS and reduced plasma triglyceride levels but did not affect endothelium-independent relaxations. Animal Model: C57BL/6J mice (ApoE −/− mice) Dosage: 15 mg/kg Administration: Chronic treatment ; daily for 6 weeks Result: Significantly increased the phosphorylated eNOS (Ser1177) and total eNOS but not the phosphorylated to total eNOS ratio in aortae of 18 weeks old ApoE −/− mice.

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