化学合成。
化学合成
合成路线 1（1. 合成：79456-34-1）
产率：98%
合成条件：With N-Bromosuccinimide In acetonitrile at 5 - 23℃; for 1 h;
实验步骤：步骤3）5-溴-3-三氟甲基 - 吡啶-2-基胺CAS-No。[79456-34-11; 在5℃下，向上述3-三氟甲基 - 吡啶-2-基胺（16.21g，100mmol）的乙腈（300mL）溶液中加入NBS（17.8g，100mmol），在23℃下搅拌。 °C，1小时。 倒入冰块并另外坐着。 用EtOAc萃取NaHCO 3溶液，用盐水洗涤，用Na 2 SO 4干燥。 真空除去溶剂得到黄色固体，将其通过硅胶和棉绒柱用二氯甲烷过滤，得到标题化合物，为黄色固体（23.71g，98％）。 MS（EI）240.1 [（M）+]，242.0 [（M + 2）+]。
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