化学合成。
化学合成
合成路线 1（1. 合成：83255-86-1）
产率：72%
合成条件：With N-Bromosuccinimide In N,N-dimethyl-formamide at 80℃; for 2.50 h;
实验步骤：将1H-吡唑并[3,4-d]嘧啶-4-胺（20.0g，148.0mmol）和N-溴代琥珀酰亚胺（27.7g，155.4mmol）悬浮于DMF（400ml）中，加热至80℃，保持2.5小时。。 冷却至室温后，用水淬灭反应（滴加，800ml）。 过滤沉淀物并悬浮在饱和Na 2 SO 3溶液（100ml）中。 过滤固体，用水（3×100ml）和冷乙醇（2×50ml）洗涤。 真空干燥后，得到3-溴-1H-吡唑并[3,4-d]嘧啶-4-胺，为米色固体（22.7g，105.9mmol，72％）。
参考文献：
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