主要用于医药领域,具体用途未在提供的信息中详细说明。
医药
合成路线 1(1. 合成:3749-21-1)
产率:94%
合成条件:With 3-chloro-benzenecarboperoxoic acid In chloroform
实验步骤:13A。 4-溴异喹啉2-氧化物在1小时内,将4-溴异喹啉(4.16g,18.6mmol)的氯仿(100mL)溶液滴加到70%mCPBA(12.4g,50.3mmol)的氯仿(100mL)溶液中。 在rt。 搅拌18小时后,将反应混合物用1N NaOH(2×150mL)洗涤,干燥(MgSO 4)并减压浓缩,得到化合物13A(4.23g,94%),为灰白色固体。 1 H NMR(400MHz,CDCl 3)δ8.71(s,1H),8.43(s,1H),8.09(d,1H,J = 8Hz),7.70(m,3H)。
参考文献:
- [1] Patent: US2004/19063, 2004, A1 [2] Patent: US2004/181064, 2004, A1 [3] Journal of Medicinal Chemistry, 1995, vol. 38, # 21, p. 4234 - 4243 [4] Chemical Communications, 2018, vol. 54, # 32, p. 3977 - 3980 [5] Organic and Biomolecular Chemistry, 2016, vol. 14, # 24, p. 5820 - 5825 [6] Organic Process Research and Development, 2006, vol. 10, # 1, p. 70 - 77 [7] Patent: WO2005/28444, 2005, A1. Location in patent: Page/Page column 51 [8] Pharmaceutical Bulletin, 1954, vol. 2, p. 72,76 [9] Patent: US2004/77605, 2004, A1 [10] Patent: US2005/119228, 2005, A1 [11] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 2, p. 939 - 950 [12] European Journal of Organic Chemistry, 2016, vol. 2016, # 8, p. 1606 - 1611 [13] New Journal of Chemistry, 2016, vol. 40, # 12, p. 10227 - 10232 [14] Organic and Biomolecular Chemistry, 2017, vol. 15, # 15, p. 3165 - 3169