作为医药中间体或活性成分,用于相关药物的合成研究(具体应用细节未明确提及)。
医药
合成路线 1(1. 合成:26138-64-7)
产率:95.7%
合成条件:With sodium In methanol; dichloromethane for 5 h;
实验步骤:向100mL圆底烧瓶中加入0.43g(18.8mmol)金属钠,30mL无水甲醇直至金属钠完全消失,加入20mL无水二氯甲烷,搅拌均匀后加入4.43g冷却混合均匀(18.8mmol)非甲酰基苯 乙酰乙酰胺,加热5h至室温,加入50mL冰水,用稀盐酸调至强酸,得到大量白色固体,过滤,用水洗涤,用乙醇洗涤固体,干燥,得到 白色固体3.66克,熔点 熔点256-257℃,收率95.7%。
参考文献:
- [1] Patent: CN103508950, 2016, B. Location in patent: Paragraph 0030; 0032 [2] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983, vol. 22, # 5, p. 496 - 498 [3] Chemistry of Heterocyclic Compounds, 2009, vol. 45, # 2, p. 169 - 175 [4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 23, p. 7147 - 7151 [5] Asian Journal of Chemistry, 2011, vol. 23, # 9, p. 4215 - 4218 [6] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012, vol. 51, # 6, p. 855 - 859