化学合成。
医药; 有机合成
合成路线 1（1. 合成：132521-66-5）
产率：68%
合成条件：With triethylamine; trichlorophosphate In toluene at 120℃; for 3 h;
实验步骤：化合物2-3的制备向2L（10g，48.5mmol）的POCl 3（80mL）溶液中加入Et 3 N（4.85g，48.5mmol）。 将溶液加热至120℃并搅拌3小时，然后真空除去溶剂。 将残余物倒入冰水中，并用DCM萃取。 将有机相用NaHCO 3和盐水洗涤，并经无水Na 2 SO 4干燥并过滤。 浓缩滤液，得到所需产物（30g，68％）。
参考文献：
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