70424-94-1 3,4,5-三(苄氧基)苯甲酸甲酯

危险性质：非危险化学品

3,4,5-三(苄氧基)苯甲酸甲酯在医药和农药领域有广泛应用，具体用途需结合相关研究和专利进一步明确。

医药; 农药

合成路线 1（1. 合成：70424-94-1）

产率：100% 合成条件：With potassium carbonate In N,N-dimethyl-formamide at 120℃; for 7 h; 实验步骤：将碳酸钾（63.31g，400mmol）和苄基溴（59.47mL，500mmol）加入到3,4,5-三羟基苯甲酸甲酯（化合物60）（18.41g，100mmol）的DMF（70mL）溶液中。）。 将该反应混合物在120℃下搅拌7小时，然后倒入水中。 用乙酸乙酯萃取混合物。 将有机层用Na 2 SO 4干燥并减压浓缩。 以定量收率得到标题化合物61（3,4,5-三苄氧基苯甲酸甲酯）（47.19g）。 化合物61的NMR光谱示于表29中。表29化合物61400MHz的NMR光谱1H NMR（CDCl3）δ7.45-7.24（17H，m，Ar-H），5.14（4H，s，ArCH2O），5.11（ 2H，s，ArCH 2 O），3.89（3H，s，CO 2 CH 3）。 参考文献：

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合成路线 2（2. 合成：70424-94-1）

产率：94% 合成条件：With potassium carbonate In dimethyl sulfoxide at 20℃; 实验步骤：将3,4,5-三羟基苯甲酸甲酯（16）（55.24g，0.3mol），苄基氯（113.93g，0.9mol），碳酸钾（124.39g，0.9mol）和碘化钾（催化量）在干燥下机械搅拌 DMSO（200mL）在室温下过夜。 加入水（200mL），过滤分离粗产物。 在真空干燥器中蒸发残余溶剂留下浅黄色固体，其基本上是纯产物。 产量：128.2g（94％）。 参考文献：

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