化学合成。
化学合成
合成路线 1（1. 合成：138786-86-4）
产率：100%
合成条件：Stage #1: at 20℃; for 16 h; Stage #2: With water; sodium hydrogencarbonate In methanol; ethyl acetate
实验步骤：参考例1 4-硝基-1H-吡唑-3-羧酸甲酯将乙酰氯（9mL）滴加到甲醇（90mL），4-硝基-1H-吡唑-3-羧酸（9.00g，57.3mmol）中 加入混合物中。 将混合物在室温下搅拌16小时，并减压浓缩。 向残余物中加入甲醇，并将混合物减压浓缩，重复该操作两次。 将残余物用甲醇和乙酸乙酯稀释。 加入5％碳酸氢钠水溶液，将pH调节至8-9。 用乙酸乙酯萃取混合物。 萃取液用水，盐水洗涤，用无水硫酸镁干燥，减压蒸发溶剂，得到标题化合物（9.83g，收率100％）。 1H-NMR（DMSO-d6,200MHz）：δ3.98（3H，s），8.28（1H，s）。
参考文献：
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