生命科学，多靶点的RTK抑制剂。
医药
合成路线 1（1. 合成：405169-16-6）
产率：88.4%
合成条件：Stage #1: at 20 - 65℃; for 2 h; Inert atmosphere Stage #2: With potassium tert -butylate In toluene at 50℃; for 2 h;
实验步骤：式1的化合物 - 乙基-2-（5-（4-甲基 - 哌嗪-1-基）-1H-苯并[d]咪唑-2-基）乙酸酯和151g的式2的化合物2-氨基-6将68g-氟苄腈混合，然后加入甲苯20倍体积的溶液，在60℃的对照温度下，减压蒸发甲苯溶液至一半体积的氮气，在刺穿10倍体积后加入甲苯溶液，和继续控制65℃以下的内部温度，在减压下蒸馏出甲苯，向残留的蒸汽中加入甲苯溶液10倍体积的氮气，检测水分，含量小于300ppm，通过后冷却至20℃，直接加入钾叔丁醇盐固体169g，在50℃下控制室温至反应2小时的温度。在5倍体积的水的反应溶液完成后，控制反应温度在室温下淬灭至40℃。条件，必须在粘性反应溶液中沉淀5倍于四氢呋喃体积的固体直至溶液澄清，加入水，用水除去水，用饱和氯化钠溶液洗涤有机相，指向水相，除去有机相。通过蒸发四氢呋喃加热沉淀出固体，冷却并过滤，得到最终产物多维伊马替尼173g，收率88.4％。
参考文献：
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