4815-28-5 2-氨基-4,5,6,7-四氢苯并[b]噻吩-3-甲酰胺

危险性质：非危险化学品

主要作为医药中间体或活性成分，用于相关药物研发与合成。

医药

合成路线 1（1. 合成：4815-28-5）

产率：90% 合成条件：With morpholine; sulfur In ethanol at 20℃; for 6 h; 实验步骤：向搅拌的化合物1（3.0g，30.56mmol），2-氰基乙酰胺（2.56g，30.56mmol），硫粉（0.97g，30.56mmol）的乙醇（40mL）溶液中加入吗啉（5.31mL，61.11mmol） ）并在室温下搅拌反应混合物6小时。 浓缩反应混合物，用EtOAc稀释并用H 2 O（2×30mL）洗涤有机层。 将分离的有机层用无水Na 2 SO 4干燥，蒸发并通过柱色谱法纯化，得到化合物2（5.40g，90％），为浅黄色固体。 ESI-MS发现197 [M + H] +。 参考文献：

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