2980-32-7 去甲基雏菊叶龙胆酮

名称和标识

中文名: 去甲基雏菊叶龙胆酮
英文名: Desmethylbellidifolin
CAS号: 2980-32-7
分子式: C13H8O6
分子量: 260.2
中文别名: 去甲基龙胆呫吨酮酚; 去甲基雏叶龙胆酮; 去甲基雏菊叶龙胆口山酮; 去甲基雏菊叶龙胆素; 1,3,5,8-四羟基呫酮; 1,3,5,8-四羟基山酮
英文别名: 1,3,5,8-Tetrahydroxy-9H-xanthene-9-one; 1,3,5,8-Tetrahydroxy-9-xanthenone; 1,3,5,8-Tetrahydroxy-9H-xanthen-9-one; 1,3,5,8-Tetrahydroxyxanthane; Desmethylbellidifoline; Norbellidifodin; Bellidin; Xanthen-9-one,1,3,5,8-tetrahydroxy; norbellidifolin; 1,3,5,8-tetrahydroxyxanthone; Desmethybellidifolin; 1,3,5,8-tetrahydroxy-xanthen-9-one; 1,3,5,8-tetrahydroxyxanthen-9-one

用途与制备

生物活性 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种从 Gentianella acuta 中提取的天然黄酮。1,3,5,8-Tetrahydroxyxanthone 具有镇痉作用和抗炎活性。
体外研究 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) attenuates lipopolysaccharide-induced nitric oxide release and proinflammatory cytokine expression in RAW264.7 cells.
体内研究 1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin; orally; 5, 10, 20 mg/kg; 12 days) can inhibit trinitrobenzenesulfonic acid (TNBS)-induced ulcerative colitis (UC), reducing inflammatory response and alleviate colon muscle spasm.
化学性质黄色结晶粉末，可溶于甲醇、乙醇、DMSO等有机溶剂。
去甲基雏叶龙胆酮具有清热解毒，抗氧活性，致突变活性的作用。

医药

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