概述
5-溴噻吩-3-羧酸可用作医药合成中间体。如果吸入5-溴噻吩-3-羧酸，请将患者移到新鲜空气处；如果皮肤接触，应脱去污染的衣着，用肥皂水和清水彻底冲洗皮肤，如有不适感，就医；如果眼晴接触，应分开眼睑，用流动清水或生理盐水冲洗，并立即就医；如果食入，立即漱口，禁止催吐，应立即就医。
医药合成中间体
合成路线 1（1. 合成：100523-84-0）
产率：70%
合成条件：With bromine In acetic acid
实验步骤：（d）5-溴-3-噻吩甲酸将含有16g Br2（0.1mol）的冰醋酸（200ml）溶液缓慢加入到3-噻吩甲酸（12.8g; 0.1mol）的100份溶液中。 毫升冰醋酸。 将混合物搅拌20分钟，然后倒入水和冰中。 将白色沉淀物过滤，洗涤并从水中结晶。 产量，70％。
参考文献：
- [1] Tetrahedron Letters, 2013, vol. 54, # 11, p. 1460 - 1462 [2] Patent: US4767758, 1988, A [3] Journal of Materials Chemistry C, 2018, vol. 6, # 14, p. 3731 - 3742 [4] Chemistry of Materials, 2010, vol. 22, # 19, p. 5617 - 5624 [5] Angewandte Chemie - International Edition, 2018, vol. 57, # 26, p. 7714 - 7718 [6] Angew. Chem., 2018, vol. 130, # 26, p. 7840 - 7844,5 [7] Patent: US2009/156615, 2009, A1. Location in patent: Page/Page column 18 [8] Journal of Materials Chemistry, 1999, vol. 9, # 9, p. 2155 - 2163 [9] Monatshefte fuer Chemie, 1989, vol. 120, p. 53 - 63 [10] Patent: US2010/29638, 2010, A1. Location in patent: Page/Page column 110 [11] RSC Advances, 2016, vol. 6, # 20, p. 16437 - 16447 [12] Organic Letters, 2011, vol. 13, # 4, p. 672 - 675 [13] Patent: WO2009/151598, 2009, A1. Location in patent: Page/Page column 129 [14] Journal of the American Chemical Society, 1954, vol. 76, p. 2445 [15] Patent: EP186252, 1992, B1 [16] Patent: WO2005/105808, 2005, A1. Location in patent: Page/Page column 26 [17] Patent: US5498630, 1996, A [18] Patent: US5840917, 1998, A [19] Patent: US2009/275585, 2009, A1. Location in patent: Page/Page column 12; 16 [20] Patent: WO2005/9941, 2005, A1. Location in patent: Page 43 [21] Patent: WO2011/33255, 2011, A1. Location in patent: Page/Page column 71-72 [22] ACS Chemical Neuroscience, 2017, vol. 8, # 1, p. 115 - 127 [23] Patent: US2003/8867, 2003, A1 [24] Patent: US2005/227959, 2005, A1. Location in patent: Page/Page column 53 [25] Patent: EP2241569, 2010, A1. Location in patent: Page/Page column 25
