体外研究
Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver.
体内研究
Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney.
Animal Model:
Male Sprague Dawley rats
Dosage:
30 mg/kg
Administration:
Oral administration, daily, for 4 weeks
Result:
Suppressed the blood pressure elevation induced by Ang I.
