吗啉-4-羧酸叔丁酯主要用于医药领域，具体用途未在提供的信息中详细说明。
医药
合成路线 1（1. 合成：220199-85-9）
产率：100%
合成条件：With guanidine hydrochloride In ethanol at 35 - 40℃; for 0.02 h;
实验步骤：一般步骤：将胺（1mmol）加入到磁力搅拌的盐酸胍（15mol％）和二碳酸二叔丁酯（1.2mmol）的EtOH（1mL）溶液中，在35-40℃下搅拌均匀 时间（表1）。 在反应完成后（接着是TLC或GC），在真空下蒸发EtOH，并用水洗涤残余物以除去催化剂或将其溶解在CH 2 Cl 2（或EtOAc）中并过滤以分离出催化剂。 蒸发有机溶剂（如果在后处理中使用）产生几乎纯的产物。 在使用过量（Boc）2O的情况下，用石油醚或己烷洗涤产物以回收残余物（Boc）2O。 如果需要，通过结晶（己烷和二氯甲烷，或乙醚和石油醚）或硅胶柱色谱法使用EtOAc-己烷（1：6）作为洗脱液进一步纯化产物。
参考文献：
- [1] Tetrahedron Letters, 2006, vol. 47, # 46, p. 8039 - 8042 [2] Synthesis, 2006, # 16, p. 2784 - 2788 [3] Tetrahedron Letters, 2008, vol. 49, # 16, p. 2527 - 2532 [4] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264 [5] Monatshefte fur Chemie, 2011, vol. 142, # 10, p. 1035 - 1043 [6] Tetrahedron Letters, 2007, vol. 48, # 47, p. 8318 - 8322 [7] Tetrahedron Letters, 2008, vol. 49, # 21, p. 3527 - 3529 [8] Synthesis, 2008, # 19, p. 3126 - 3130 [9] Tetrahedron Letters, 2009, vol. 50, # 46, p. 6244 - 6246 [10] Asian Journal of Chemistry, 2017, vol. 29, # 6, p. 1313 - 1316 [11] Organic Letters, 2006, vol. 8, # 15, p. 3259 - 3262 [12] Comptes Rendus Chimie, 2010, vol. 13, # 5, p. 544 - 547 [13] Synthetic Communications, 2012, vol. 42, # 1, p. 25 - 32 [14] Letters in Organic Chemistry, 2011, vol. 8, # 1, p. 38 - 42 [15] Letters in Organic Chemistry, 2012, vol. 9, # 3, p. 165 - 168 [16] RSC Advances, 2016, vol. 6, # 82, p. 78576 - 78584 [17] Journal of Organic Chemistry, 2004, vol. 69, # 2, p. 577 - 580 [18] Tetrahedron Letters, 2010, vol. 51, # 29, p. 3855 - 3858 [19] Tetrahedron Letters, 2006, vol. 47, # 43, p. 7551 - 7556 [20] Journal of the Chilean Chemical Society, 2013, vol. 58, # 1, p. 1619 - 1623 [21] Research on Chemical Intermediates, 2016, vol. 42, # 2, p. 1451 - 1461 [22] New Journal of Chemistry, 2018, vol. 42, # 12, p. 10142 - 10147 [23] Journal of Organic Chemistry, 2006, vol. 71, # 21, p. 8283 - 8286 [24] Tetrahedron Letters, 2012, vol. 53, # 43, p. 5803 - 5806 [25] Letters in Organic Chemistry, 2013, vol. 10, # 2, p. 121 - 125 [26] Journal of Chemical Research, 2013, vol. 37, # 12, p. 757 - 760 [27] Tetrahedron Letters, 2010, vol. 51, # 49, p. 6388 - 6391 [28] Synthetic Communications, 2011, vol. 41, # 5, p. 715 - 719 [29] Synlett, 2006, # 7, p. 1110 - 1112 [30] Tetrahedron Letters, 2004, vol. 45, # 37, p. 6963 - 6965 [31] Advanced Synthesis and Catalysis, 2005, vol. 347, # 15, p. 1929 - 1932 [32] Tetrahedron Letters, 2007, vol. 48, # 33, p. 5865 - 5868 [33] Tetrahedron Letters, 2017, vol. 58, # 7, p. 629 - 633 [34] Chemistry - A European Journal, 2018, vol. 24, # 32, p. 8051 - 8055 [35] Organic Letters, 2018, vol. 20, # 18, p. 5661 - 5665
