化学合成。
化学合成
合成路线 1（1. 合成：13720-94-0）
产率：87%
合成条件：Stage #1: at 110℃; for 0.33 h; Stage #2: With ammonia In water at 0℃;
实验步骤：4-氯喹啉-3-羧酸乙酯（A2）; 向固体的4-羟基喹啉-3-羧酸乙酯（A1）（1.5g，7mmol）中加入POCl 3（2.2g，1.3mL，14mmol）并将混合物在110℃加热20分钟。 将混合物倒入NH 3（水溶液，28-30％）和冰中，然后搅拌至粒状。 将熔化的冰混合物用乙醚（3×40mL）萃取，将合并的有机层干燥（MgSO 4），过滤并浓缩，得到油状产物，其在静置时结晶（1.44g，6mmol，87％），原样使用 进一步净化。
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