化学合成。
化学合成
合成路线 1（1. 合成：87630-35-1）
产率：98%
合成条件：Stage #1: With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.50 h; Inert atmosphere Stage #2: at -78℃; for 5 h; Inert atmosphere
实验步骤：在-78℃下，将n-BuLi（1.57M，在正己烷中，17.3mL，27.1mmol）滴加到吡咯（19,1.52g，22.6mmol）的THF（36mL）溶液中，并且整个混合物 在-78℃下搅拌30分钟。 向混合物中加入TIPSCl（5.3mL，24.9mmol），并将全部混合物在-78℃下搅拌5小时。星期六 NH4Cl aq。 在0℃下向混合物中加入，并用AcOEt萃取整个混合物。 在减压下从AcOEt萃取物中除去溶剂，得到粗产物，将其通过SiO 2柱（正己烷/ AcOEt = 10：1）纯化，得到1-三异丙基硅烷基-1H-吡咯（4.94g，98％），为 无色油。
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