作为医药中间体或活性成分,用于相关药物研发(基于文献[1]等医药化学研究)。
医药
合成路线 1(1. 合成:143141-23-5)
产率:99%
合成条件:Stage #1: With tetrabutylammomium bromide; sodium hydroxide In dichloromethane Stage #2: at 0 - 20℃;
实验步骤:4.2.4 1-(苯磺酰基)-1H-吡咯并[2,3-b]吡啶(5)在加热干燥和氮气吹扫的圆底烧瓶中,1H-吡咯并[2,3-b]吡啶1(1.01g,将8.58mmol),四丁基溴化铵(81mg,0.25mmol),精细研磨的氢氧化钠(1.02g,25.41mmol)和CH 2 Cl 2(20mL)混合,搅拌并在冰浴中冷却至0℃,然后苯磺酰氯缓慢加入(1.35mL,10.59mmol)。将混合物温热至室温并在该温度下搅拌1小时。将反应用水(20mL)水解并用CH 2 Cl 2萃取(两次)。用饱和氯化钠溶液洗涤有机层,用硫酸镁干燥,减压浓缩,得到2.38g米色固体。通过硅胶柱色谱,环己烷/ EtOAc 7:3纯化粗产物,得到2.17g纯的预期产物,为白色固体,收率99%。 1H NMR(300MHz,CDCl3)δ(ppm):8.45(dd,J = 1.5,4.8Hz,1H),8.20(d,J = 7.5Hz,2H),7.86(dd,J = 1.5,7.8Hz, 1H),7.73(d,J = 4.0Hz,1H),7.57(dd,J = 7.4Hz,1H),7.52-7.47(m,2H),7.19(dd,J = 4.8,7.8Hz,1H), 6.61(d,J = 4.0 Hz,1H)。 13 C NMR(75MHz,CDCl 3)δ(ppm):144.7(2C),138.3,134.1,129.9,129.1(2C),128.0(2C),126.5,123.0,119.0,105.5。
参考文献:
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